Category Archives: The Rheuma Muse

The 9 Muses are daughters of Zeus and Mnemosyne, Greek goddesses personifying the inspiration for the sciences and the arts.
My highly opinionated news-blog draws inspiration from both the science and the art of Rheumatology.

Immunology of Infection

Human Immune System Likened to Model of Military Efficiency It’s a system under “very tight regulation,” Dr. Torgerson said, with factors essentially holding… Ten Strategies of Interferon Evasion by Viruses Viruses are formidable pathogens that take advantage of the infected cell machinery while disarming the antiviral host defenses. García-Sastre reviews the most common mechanisms…
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Septic Shock

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries. The Magic Bullet in Sepsis or the Inflation of Chance Findings? FINANCIAL/NONFINANCIAL DISCLOSURES: The…
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Th1 Differentiation Drives the Accumulation of Intravascular, Non-protective CD4 T Cells during Tuberculosis Sallin et al. show that IL-12/23p40 and T-bet… Transcription Factor T-bet Orchestrates Lineage Development and Function in the… T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives…
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Herpes Zoster

Herpes simplex virus and varicella zoster virus, the house guests who never leave Human alphaherpesviruses including herpes simplex viruses (HSV-1, HSV-2) and varicella zoster virus (VZV) establish persistent latent infection in sensory neurons for the life of the host. All three viruses have the potential to reactivate causing recurrent disease. Regardless of the homology betwee...…
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