Behcet's Disease has a somewhat "mysterious" prevalence, occurring almost exclusively among peoples originating along the ancient Silk Road. As such, genetic factors are believed to play a significant role.
While orogenital ulceration is its most common manifestation, ocular and neurological involvements are its most devastating, bringing the patients to clinical presentation.
Various biologics, especially the anti-TNFs, have been found to be highly effective for treating these major complications.
Behçet’s disease in children, an overview. For severe manifestations involving the eye, brain or gut, the anti-TNFs are replacing steroids as the standard of care.