Gout Roundup

Gout and Pseudogout: Practice Essentials, Background, Pathophysiology

Gout and pseudogout are the two most common crystal-induced arthropathies. Gout is caused by…

emedicine.medscape.com


Review: Gout: A Roadmap to Approaches for Improving Global Outcomes

onlinelibrary.wiley.com


Gout: top 10 tips for patient and doctor - Dr David O'Reilly

Gout, urate, uric, Rheumatologist, Allopurinol, colchicine, febuxostat

Gout isn't just about the joints it is linked to increased risk of heart attack and stroke. Read…

rheumatologyuk.com


SUA levels should not be maintained < 3 mg/dL for several years. Response to ‘EULAR gout treatment guidelines by Richette et al: uric acid and neurocognition by Singh et al’

Image result for allopurinol

We thank Drs Singh and Edwards for their interest in our 2016 revised EULAR recommendations for the management of gout.1 Drs Singh and Edwards were concerned about the latter part of our sixth recommendation, in which we indicate that a serum uric acid (SUA) level mg/dL (<180 µmol/L) is not recom...

ard.bmj.com

At diagnosis, Gout should be treated aggressively and promptly to target a serum uric acid level well below its crystallization concentration of 6.8 mg% at core body temperature. The conventional target is 6 mg%.

However, in the cooler peripheries, and in the presence of nucleation framework (old injuries, existing tophi), precipitation may well occur at lower serum concentrations. I thus advocate 5 mg%.

The lower you go, the faster you'll clear the deposits and the total body urate burden. But there are concerns, both theoretical and evidential, that, maintaining too low (below 3 mg%) a target may prove detrimental in the long run. As in all things, moderation is the better part of prudence.

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