Immunology of Autoimmunity

A Brief History of IL-1 and IL-1 Ra in Rheumatology

The history of what, in 1979, was calledinterleukin-1(IL-1), orchestrator of leukocyte inter-communication, began many years before then, initially by the observation of fever induction via the endogenous pyrogen (EP) (1974) and…
journal.frontiersin.org

Interleukin‐9 and T helper type 9 cells in rheumatic diseases

Figure 1.

Interleukin (IL)‐9 is a 28‐30 kDa monomeric glycosylated polypeptide belonging to the IL‐7/IL‐9 family of proteins that bind to a composite receptor consisting of the private receptor IL‐9R…

Direct in vivo effect of NFAT5 in macrophages on the progression of arth...

1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea,…
jci.org

Innate Lymphoid Cells Play Key Role in Rheumatic Diseases

Balancing between tissue homeostasis and inflammation
medpagetoday.com

Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes

Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes…
dovepress.com

Epigenetics of CD4+ T cells in autoimmune diseases

Purpose of review: Autoimmune disorders are a group of overactive symptoms because of…
journals.lww.com

Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation

13C2 T cells can adopt a Tfh cell phenotype and induce AM14 B cells to d...

3Division of Rheumatology, Department of…
insight.jci.org

B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis

Objectives TNFSF4 (encodes OX40L) is a susceptibility locus for systemic lupus erythematosus (SLE). Risk alleles increase TNFSF4 expression in cell…
ard.bmj.com

Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy

Apoptotic cell-based therapies have been proposed to treat chronic inflammatory diseases. The aim of this study was to investigate the effect of intravenous (i.v.) apoptotic cell infusion in ongoing collagen-induced arthritis (CIA) and the interaction of this therapy with other treatments used in rh...
arthritis-research.biomedcentral.com

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