Myopathy & Myositis

neuromuscular.wustl.edu

This is an exhaustive list of drugs which may (rarely apart from steroids) cause clinically relevant myopathy/myositis. I would like to draw your attention to Colchicine, which we often use longterm for conditions as common as Gout to uncommon ones like Behçet's and some other vasculitides. Though overwhelmingly asymptomatic in those with normal renal function, I've been cautioned by my neurology colleagues not to order EMG for patients on Colchicine as it will turn out invariably abnormal. I wonder if this applies also to any of the other drugs on this very exhaustive list.


Statin-Induced Autoimmune Myopathy

The CDC estimates that nearly 71% of adults with cardiovascular disease and 54% of adults with hypercholesterolemia use a cholesterol-lowering medication and…

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Myositis antibodies, clinical features may predict disease course in juvenile patients

Myositis autoantibodies, particularly anti-p155/140, certain clinical features and environmental…

www.healio.com


Juvenile Dermatomyositis Responds Best to Methotrexate and Prednisone

Lancet reports the results of a randomized…

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Challenges of Dermatomyositis Progress

In the current issue of Lancet, Pierre Miossec discusses the challenges of studying and managing juvenile dermatomyositis and, specifically, the PRINTO trial…

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Correspondence from The New England Journal of Medicine — Remission of Recalcitrant Dermatomyositis Treated with Ruxolitinib
www.nejm.org

When even throwing the kitchen sink (and that includes steroids, MTX, Azathioprine, cyclophosphamide, IVIG, Rituximab) fails in refractory DM/PM (and it's really autoimmune myositis and not Inclusion Body Myositis), perhaps Ruxolitinib may work? But, in this case report, does it work directly on the immune response by inhibiting JAK 1/2, or indirectly through remitting Myelofibrosis?
How about our fave pan-JAK inhibitor: Tofacitinib? Are the JAK inhibitors turning out to be a JAcK of all trades?

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