Obesity & Autoimmunity

Obesity has an established systemic inflammatory component. Could that be a trigger for the inflammation seen in rheumatoid arthritis (RA) and other rheumatic diseases? Although there is no direct scientific evidence, both mechanistic and epidemiologic clues do give some intriguing suggestions of a…
www.the-rheumatologist.org|By Kurt Ullman

Rheumatoid arthritis patients who smoke or are overweight see less symptom improvement with treatment

Smoking or being overweight makes it more difficult for patients with rheumatoid arthritis to achieve optimal control of inflammation and symptoms, despite standard of care treatment.

Fat is bad for RA.

DENVER – Weight loss enhances responsiveness of patients with psoriatic arthritis to tumor necrosis…

Fat is bad for Psoriasis & Psoriatic Arthritis.

Development of secondary failure to biologics over time in Psoriatic Arthritis and Psoriasis may be due to the development of anti-drug antibodies, especially since the combination with a conventional immunosuppressive DMARD has not been shown to be more efficacious (and therefore unnecessary).
Excessive weight gain is another possible factor, either due to increased volume of drug distribution, or to the pro-inflammatory nature of fat, or both.
The converse, as suggested by this study, is also true.

Bariatric Surgery Thwarts Gout and Hyperuricemia

The rising incidence of gout has been directly linked to the obesity epidemic.  The influence of obesity on…

 Fat is bad for Gout.

The Pounds on Your Body Are Taking Points off Your Brain

Excess weight brings on inflammation inside your body. That's bad for your brain and mental abilities.

Fat is bad for your brain, makes you lazy and stupid.

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