In the 2-year Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) study, the aim was to study the effect of a 15% weight loss on various health measures. This was expected to be achievable through a 25% drop in caloric intake.
Although the spirit was willing, the weak flesh could barely attained half of the calorie restriction on average. Despite this, significant cardiovascular risks were favourably modulated: blood pressure, cholesterol and insulin resistance.
Most interestingly, the inflammation marker, C-Reactive Protein(CRP), almost halved! This comes closest to drawing the link between calorie intake and inflammation, and indirectly between obesity and inflammatory diseases.
This raises some interesting questions:
1) Is the link with inflammation with total calorie intake, or is there a specific food group (carbohydrates, fats or proteins) that is particularly pro-inflammatory? If so, why? My bet is with carbs, especially fructose;
2) Would weight loss through non-dietary means (exercise, bariatric surgery) result in similar benefits?