Obesity

Obesity and Infection Risk in Joint Replacement

Joint replacement surgery can dramatically improve the quality of life in an individual who has a successful result.  To the contrary, if you have a compli

www.howardluksmd.com


The overweight suffer a ‘vicious circle’ of perception and behavior, according to psychologist Jessica Witt: ‘You’re seeing the world in terms of your ability to act’
www.theguardian.com|By Alan Yuhas

We perceive the world not as it is, but based on our perceived ability to act.

We are all cognizant of the physical constraints obesity places on us physically: degenerative arthritis, metabolic diseases, poor surgical outcomes, body image, depression even. We are less aware of how it subconsciously restrains us from attempting and achieving our aspirations and potential in life.


Drinking sugar-sweetened beverages like soda daily may lead to more abdominal fat gain over time, according to a new study.
www.channelnewsasia.com

Fruit sugar may well lie at the heart of our obesity and metabolic epidemic, and this means hypertension, diabetes, dyslipidaemia, gout and cardiovascular disease too.
Perhaps we should start eating healthier by reigning in soft drinks and juicing.


Photo published for Fructose Metabolism
Increased fructose consumption is a controversial issue of late, being blamed, in part, for the rise of obesity. What can isotopic tracing tell us about the metabolism of dietary fructose in humans?
www.medscape.com

As evident from the earlier "popular press" article I posted, FRUCTOSE has become a convenient bogeyman in the great American obesity epidemic blame game. But what is the scientific basis, if any?

Firstly, looking at the metabolic pathway of fructose in the human body:
https://upload.wikimedia.org/…/a/…/Fructose-triglyceride.jpg
fructokinase effectively traps the absorbed fructose in the liver, eventually metabolising it to triglyceride for storage: ie FAT. It is tempting to draw a relationship to it causing fatty liver as well.

Secondly, that first step phosphorylation uses more energy (ATP) than it generates directly, resulting in the generation of uric acid:
http://watcut.uwaterloo.ca/…/gr…/fructose-gout-pic-9428d.png
thus providing yet another simplistic explanation linking fructose to GOUT.

But truth is never simplistic, and seldom simple, as this article shows. Most of the fructose consumed is converted into energy, glucose, glycogen or lactate, with <1% channeled to TG formation directly. In other studies, the proportion of daily uric acid generation attributable to fructose metabolism appears insignificant. Of course, these experiments do not address whether excessive fructose consumption may tip the balance.

The truth of obesity is, as it always has been: too much consumption (of any caloric source) with too little expenditure (exercise).

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