Osteoporosis

A one-year observational study compared switching from daily TPTD to either oral bisphosphonates (BP) therapy or denosumab (DMAb) in patients with primary…
rheumnow.com

Current safety data for Teriparatide restrict continuous usage to no more than 2 years. As the bone turnover cycle is tightly coupled, the sudden withdrawal of bone formation stimulation will lead to rapid net bone loss due to unbridled bone resorption. Teriparatide should logically be followed on with an anti-resorptive agent, eg Bisphosphonates, Denosumab.


Objectives Concerns have been raised about a possible link between bisphosphonate use, and in particular alendronate, and upper gastrointestinal (UGI) cancer. A number of epidemiological studies have been published with conflicting results. We conducted a systematic review and meta-analysis of obser…
m.bmjopen.bmj.com

Bisphosphonates are the most widely used anti-osteoporosis drugs. It has prevented far more fractures and saved more lives than all its side-effects put together.
Owing to its propensity to cause oesophagitis especially if taken reclined, one of the concerns is regarding the risk for developing oesophageal and gastric cancers. It is soundly debunked in this most comprehensive meta-analysis to-date.


Gastroesophageal reflux disease (GERD) with proton pump inhibitor (PPI) use is associated with an increased risk of osteoporosis. The risk of hip fracture is not…

link.springer.com


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onlinelibrary.wiley.com

Osteonecrosis (bone death) of the jaw is a known side-effect of anti-resorptive usage, but extremely rare. It may be due to a combination of causes, like over-suppression of bone turnover compromising bone repair, and suppression of scavenger immune cells impairing defence against mouth bacteria. This article examines how this dreaded complication can be prevented, detected and treated.

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