Ankylosing Spondylitis patients have significant comorbidities. In this 3-year follow-up from initial AS diagnosis, there were significant increased incidences of comorbidities, especially of conditions known to be associated with AS from a pathogenesis basis, such as Uveitis, Inflammatory Bowel Disease, and Osteoporosis.
Lesser known comorbidities include sleep apnoea, asthma, cardiovascular diseases, and cancers.
Cancer risk is increased in patients with Ankylosing Spondylitis, especially gastrointestinal and haematological malignancies.
A new diagnosis of Ankylosing Spondylitis is associated with sleep disorder, anxiety and depression.
The latter may be reactive to the pain and disability, or a direct effect of systemic inflammation.