AS: Detecting Disease Activity

Plasma, urine and ligament tissue metabolite profiling reveals potential biomarkers of ankylosing spondylitis using NMR-based metabolic profiles

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Ankylosing spondylitis (AS) is an autoimmune rheumatic disease mostly affecting the axial skeleton. Currently, anti-tumour necrosis factor α (anti-TNF-α) represents an effective treatment for AS that may delay the progression of the disease ...

Inconsistent ESR & CRP in Spondylitis Patients

Patients with active axial spondyloarthritis (axSpA) can lack evidence of inflammation on magnetic resonance imaging (MRI) but may develop evidence of inflammation over time.

Inflammation Not Always Present with Active Spondyloarthritis

About 50% of patients will develop objective signs of inflammation within 12 weeks

Nonradiographic Axial Spondyloarthritis May Be Revealed by MRI

These results suggest that patients with nonradiographic axial spondyloarthritis who have no radiographic evidence of sacroiliac joint structural lesions may have underlying erosions detectable by MRI
Are underlying sacroiliac erosions present in patients with nonradiographic axial spondylarthritis who have normal radiographs?

Sacroiliac structural changes show on MRI in nonradiographic axial SpA despite no inflammation

A study lends evidence for justifying earlier treatment with biologics for some patients.

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