Chronic Fatigue Syndrome

Chronic fatigue syndrome (CFS) is a disorder characterized by a state of chronic fatigue that persists for more than 6 months, has no clear cause, and is accompanied by cognitive difficulties. CSF was initially termed encephalomyalgia (or myalgic encephalomyelitis) because British clinicians noted t…
emedicine.medscape.com

It is still highly controversial whether CFS/ME is a distinct disease entity, or merely an extreme expression of a symptom.


Researchers identify metabolite disturbances in patients with chronic fatigue syndrome

Recently published results indicated chronic fatigue syndrome is a conserved, hypometabolic response…
healio.com

Selfreported Fatigue score is registered every second week, as the mean score for the four symptoms: “Post-exertional malaise”, “Fatigue”, “Need for rest”, “Daily functioning” (scale 0-6). Mean Fatigue scores for the time intervals 0-4, 4-8, 8-12, 12-16, 16-20, 20-24 months are recorded for each pat…
clinicaltrials.gov

It’s not hocus-pocus. B-cell depletion for treating CFS is now in phase 3, expecting completion and results late 2017. Encouraging results, initially a case series published in 2009, followed by a double-blind placebo-controlled trial in 2011, led to this.

Benefit from B-Lymphocyte Depletion Using the Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome. A Double-Blind and Placebo-Controlled Study

Background Chronic fatigue syndrome (CFS) is a disease of unknown aetiology. Major CFS symptom relief during cancer chemotherapy in a patient with synchronous CFS and lymphoma spurred a pilot study of B-lymphocyte depletion using the anti-CD20 antibody Rituximab, which demonstrated significant clini…
journals.plos.org