Epigenetic Immune Variation

Shaping Variation in the Human Immune System

Immune responses demonstrate a high level of intra-species variation, compensating for the specialization capacity of pathogens. The recent advent of in-depth immune phenotyping projects in large-scale cohorts has allowed a first look into the factors that shape the inter-individual diversity of the...

Where you live shapes your immune system more than your genes

Like fingerprints, immune systems vary from person to person. And although we all inherit a unique set of genes that help us respond to infections, recent studies…

Perfect timing: Epigenetic regulation of the circadian clock

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In mammals, higher order chromatin structures are critical for downsizing the genome (packaging) so that the nucleus can be small. The adjustable density of chromatin also regulates gene expression, thus...

Circadian rhythm‐related genes: implication in autoimmunity and type 1 diabetes

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Recent gene association and functional studies have proven the implication of several circadian rhythm‐related genes in diabetes. Diabetes has been…

Circadian rhythms in liver metabolism and disease

The suprachiasmatic nucleus (SCN) generates endogenous biological rhythms, ...

Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, type 2 diabetes and dyslipidemia. Here,...

Circadian Disruption: Potential Implications in Inflammatory and Metabolic Diseases Associated With Alcohol

The suprachiasmatic nucleus (SCN) is the central circadian pacemaker. The SCN is located in the hypothalamus and is regulated by light signals from the eye. The SCN then affects a wide variety of physiological and behavioral outcomes.

FULL TEXT Abstract: Circadian rhythms are a prominent and critical feature of cells, tissues, organs, and behavior that help an organism function most efficiently...
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