Infection & Autoimmunity

How Rheumatoid Arthritis Can Result from Provocation of the Immune System by Microorganisms and Viruses

The pathogenesis of rheumatoid arthritis (RA), similar to development of a majority of inflammatory and autoimmune disorders, is largely due to an inappropriate or…

Apoptosis in response to microbial infection induces autoreactive TH17 cells

Autoimmunity can often be associated with prior infection. Blander and colleagues demonstrate a mechanism by which self-tolerance can be broken after the presentation of antigens derived from bacteria-infected apoptotic cells.

Dead Cells, Disrupted Lysosomes and Lupus

In this Q&A, Rheumatology Network speaks with Dr. Barbara Vilen who is making strides in both basic and translational research that may lead to new…

Memory γδ T Cells–Newly Appreciated Protagonists in Infection and Immunity

Despite the potential for diversity in their T cell receptor, γδ T cells are primarily considered to be innate immune cells. Recently, memory-like γδ T cell responses have been identified in murine models of infection and autoimmunity. Similar memory responses have also been described in human and n...

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