Comparative effectiveness of dextrose prolotherapy versus control injections and exercise in the management of osteoarthritis pain: a systematic review and meta-analysis
PRP bests Hyaluronic Acid and saline for pain relief and functional improvement in knee OA at 1 year post-injection.
Efficacy of Platelet-Rich Plasma versus Hyaluronic Acid for treatment of Knee Osteoarthritis: A systematic review and meta-analysis
The improved clinical outcomes as well as the imaging evidence of structural cartilage reconstitution bode well for mesenchymal stem cell therapy as potentially the treatment of choice for knee OA in future.
Matrix-induced Autologous Chondrocyte Implantation (MACI) has been around for quite awhile now, but its recent FDA approval was helped by a comparative study demonstrating its superiority to the traditional microfracture procedure.
Targeted therapies are finding their way into OA treatment. Wnt inhibition holds promise as a true Disease-modifying OA drug (DMOAD) by increasing cartilage formation, in addition to symptoms relief.