Metformin, Aging & Cancer

To most of the scientific community, “anti-aging” is a dirty word. A medical field historically associated with charlatans and quacks, scientists have strictly…
singularityhub.com

So you can’t afford regular mesenchymal stem cell infusions to replenish your cells’ dying batteries (mitochondria) with fresh robust ones. Fret not. METFORMIN may just be that elixir of longevity to rescue your aging mitochondria!

I first posted on METFORMIN on Jan 15, focusing on its effects on suppressing inflammation, apart from its metabolic role in controlling metabolic conditions like Type 2 Diabetes Mellitus and Obesity.  Today, I’ll explore its possible anti-aging and anti-cancer properties.


Metformin pathways: pharmacokinetics and pharmacodynamics

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Metformin is a first-line therapy for type 2 diabetes mellitus (T2DM, formerly ‘non-insulin-dependent diabetes mellitus’), and is one of the most commonly prescribed…
ncbi.nlm.nih.gov


New mechanisms of metformin action: Focusing on mitochondria and the gut

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The most well-known mechanism of metformin action, one of the most commonly prescribed antidiabetic drugs, is adenosine…
ncbi.nlm.nih.gov


Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

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Metformin has been a first-line treatment for type II diabetes mellitus for decades and is the most widely prescribed antidiabetic drug. Retrospective studies have found that metformin treatment is associated with both reduced cancer diagnoses and cancer-related deaths. Despite the prevalence of met…
bmcbiol.biomedcentral.com